miR ‐493 by regulating of c‐Jun targets Wnt5a/ PD‐L1 ‐inducing esophageal cancer cell development
نویسندگان
چکیده
منابع مشابه
PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a
BACKGROUD The purpose of this study was to elucidate the regulation of programmed death ligand 1 (PDL1), lactate dehydrogenase A (LDHA) and miR-34a in triple negative breast cancer (TNBC) and to explore the function and mechanism of PDL1 and LDHA as competitive endogenous RNAs (ceRNAs) in TNBC via regulation of miR-34a. METHODS Western blotting, quantitative RT-PCR (qRT-PCR) and immunohistoch...
متن کاملMiR-493 suppresses the proliferation and invasion of gastric cancer cells by targeting RhoC
Objective(s):MiRNAs have been proposed to be key regulators of tumorigenesis, progression and metastasis. However, their effect and prognostic value in gastric cancer is still poorly known. Materials and Methods: Gastric cancer cell lines were cultured. Tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time PCR (qRT-PCR) analysis. The tissue microarrays (T...
متن کاملPDL1 Regulation by p53 via miR-34.
BACKGROUND Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non-small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that PDL1 is regulated by p53 via miR-34. METHODS p53 wild-type and p53-deficient cell lines (p53(-/-) and p53(+/+) HCT116, p53-inducible H1299, and p53-knockdown H460) were used to determine if p5...
متن کاملmiR‑210 regulates esophageal cancer cell proliferation by inducing G2/M phase cell cycle arrest through targeting PLK1.
micro (mi)RNAs are short regulatory RNAs that negatively modulate protein expression at the post‑transcriptional level, and are being considered as novel therapeutic targets for the treatment of cancer. In the present study, an elevated expression level of circulating miR‑210 was observed in patients with esophageal squamous cell carcinoma (ESCC) for the first time, to the best of our knowledge...
متن کاملmiR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1.
The expression of microRNA-203 (miR-203) in esophageal squamous cell carcinoma (ESCC) tissues is remarkably lower than that in non‑ESCC tissues. We investigated how miR-203 could influence the development of ESCC cells. Our analyses revealed that miR-203 inhibited the migration and invasion of ESCC cells. Genome-wide gene expression data and targe...
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ژورنال
عنوان ژورنال: Thoracic Cancer
سال: 2021
ISSN: 1759-7706,1759-7714
DOI: 10.1111/1759-7714.13950